Multi-scale data-driven modeling and observation of calcium puffs
نویسندگان
چکیده
منابع مشابه
Multi-scale data-driven modeling and observation of calcium puffs.
The spatiotemporal dynamics of elementary Ca(2+) release events, such as "blips" and "puffs" shapes the hierarchal Ca(2+) signaling in many cell types. Despite being the building blocks of Ca(2+) patterning, the mechanism responsible for the observed properties of puffs, especially their termination is incompletely understood. In this paper, we employ a data-driven approach to gain insights int...
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چکیده ندارد.
15 صفحه اولNuclear calcium signalling by individual cytoplasmic calcium puffs.
It is known that the nucleoplasmic ionised calcium concentration (Can) controls nuclear functions such as transcription, although the source and nature of the signals which modulate Can are unclear. Using confocal imaging, we investigated the subcellular origin of Can signals in Fluo-3-loaded HeLa cells. Our data indicate that all signals which increased Can were of cytoplasmic origin. Can was ...
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ژورنال
عنوان ژورنال: Cell Calcium
سال: 2012
ISSN: 0143-4160
DOI: 10.1016/j.ceca.2012.04.018